The most common types of mental illness, depression affects more than a quarter of adults in the United States. At one point, affected individuals may experience feelings of despair, hopelessness and / or guilt that interferes with daily tasks. According to a recent Gallup poll, depression costs the workplace $ 23 billion in absenteeism alone! However, the cost of human disease is much higher.
In the United States, about 60 percent of people who commit suicide had depression or another mood disorder. A disproportionate number of the group had already been diagnosed with the most severe type of depressive disorder – major depression. Now the leading cause of disability in the United States for 15-44 years, major depressive disorder strikes between 3 to 5 percent of Americans each year.
What makes it different?
Although serious, one in four adults in the United States who suffer from depression often have one or two bad days in a row in which they are admittedly “depressed” or “blue.” This may encourage them to take a mental health day to treat your depression, either on your own or with professional help. But when those who feel helpless, hopeless, sad persist for more than two weeks, the regular issue can cause a debilitating mental illness.
As the regular depression, depressive episodes may occur spontaneously or in response to an event in the life unpleasant, like the loss of a loved one, a romantic weekend, or problems at work. Unlike regular depression, both emotional and physical symptoms of the disease have not decreased for two weeks with no sign of relief. As a result, some people who suffer from clinical depression may begin to feel that your life is not worth living.
The increased risk of suicide only way to make this the most serious and severe disease. Risk New good is that with the right combination of prescription drugs and counseling, major depression is a treatable illness. Because it is a long-term illness, or even a lifetime, many patients are in and out of drugs for years at a time. The challenge for physicians is to find the antidepressants that work well with minimal side effects.
The most popular antidepressants
Because it is a common disorder, there are dozens of antidepressants on the market today. The specifically designed for depressive episodes generally fall into one of two classes of compounds: serotonin reuptake inhibitors (SSRIs) or selective serotonin reuptake inhibitors and inhibitors of norepinephrine reuptake (SNRI). As they are generally safer and have fewer side effects, doctors often begin prescribing SSRIs such as Prozac, Paxil, Zoloft or. They can also select a brand name of the SNRI class, like Cymbalta, Pristiq or Fetzima. However, people are seeking alternatives to SSRI antidepressants and espeically alternatives. But when it comes to lesser-known classes of drugs and medications that do not exactly match one of the classes, doctors are often reluctant to prescribe to their patients. Such is the case with tianeptine, a promising antidepressant that has been largely ignored for more than a half century.
What is tianeptine?
Tianeptine was discovered and patented by the French Society for Medical Research in 1960, tianeptine is available in a number of European, Asian and Latin America. However, the drug that is used primarily for the treatment of clinical depression is not prescribed in Canada, the United Kingdom, the United States, Australia and New Zealand. One reason for its limited availability, it is, once again, that tianeptine not exactly known to a class of antidepressants. In fact, it was mislabeled as an activator of the reuptake of serotonin (SSRE) until recently. We also know that tianeptine has pharmacological properties that have left researchers scratching their proverbial head of how the drug produces its antidepressant effects disparate and chemicals. One thing we do know, however, is that tianeptine works, and works well!
Tianeptine has a chemical structure consisting of three rings of atoms, tianeptine is classified as tricyclic antidepressants (TCA). But as mentioned, their pharmacological properties have been mistakenly attributed to its function as an enhancer of serotonin reuptake (SSRE) until recently. In fact, it was not until July 2014 that the new research found that the antidepressant effects of drugs are due to the indirect alteration of AMPA and NMDA glutamate, which is thought to alter neuroplasticity and trigger the release of brain-derived neurotrophic factor (BDNF).
Tianeptine acts by stimulating point hedonic or pleasure in the brain that are responsible for feelings of satisfaction and well-being. As an anxiolytic, the drug also reduces anxiety and inhibits dysphoria. This rare combination makes tianeptine a promising option for those suffering from major depression that is triggered by an anxiety disorder.
How well does it work?
As the most widely used antidepressant tricyclic (TCA), amitriptyline is on the list of essential drugs of the World Health Organization. Approved for use in 1961, has been a reference point for all other drugs in its class since. In fact, many researchers believe that amitriptyline may have superior efficacy that many, even most, SSRIs and SNRIs in the treatment of major depressive episodes. Surprisingly, tianeptine compares favorably with the popular pill in many key areas.
Researchers do not know how it works, but the efficacy of tianeptine against major depression was never in doubt. Amitriptyline report, imipramine, maprotiline, and other ATC tianeptine has far fewer side effects. He played well against the same fluoxetine (Prozac alias), the most prescribed SSRIs. Tianeptine has an advantage over most antidepressants is its remarkable anxiolytic properties. This is important because anxiety is one of the most common symptoms of clinical depression. Accordingly, tianeptine has proven effective in treating a variety of anxiety disorders which are often involved in major depressive disorders, including panic disorder, post-traumatic stress.
Tianeptine can also have a beneficial effect on cognition, in part because of their relative lack of sedative properties. After numerous studies, somnolence was a side effect of medication uncommon. Tianeptine also compares favorably with other antidepressants tolerance tests, where subjects consistently reported fewer and less severe side effects of the treatment.
There are several reasons why tianeptine not considered a first-line antidepressant. For starters, it belongs to a class of drugs more (ATC), which generally have a higher risk of toxicity in overdose and less tolerance of new drugs and drug classes SSRIs IRSN. Second, it is not sold in many countries. It is this last fact is particularly surprising because many clearly lower in their class drugs are widely available. As mentioned above, tianeptine also showed effective against episodes of depression such as amitriptyline (tricyclic antidepressants most popular), but with far fewer side effects. The same drug has advantages over SSRIs and SNRIs, which are distributed hundreds of millions of prescriptions annually in the United States.
As popular as they can be, it is well established as amplifiers (SSRIs and SNRIs) are causing problems in the bedroom. Decreased libido, delayed sexual arousal and orgasm silent or absent are common symptoms of these drugs. Because it does not directly affect the level of serotonin, taking tianeptine not cause sexual side effects. In fact, there is evidence that sexual function may actually improve Polish combining state of mind and not stimulating agents against non-sedating anxiety. It is absolutely one of the best alternatives to SSRIs there, but “no” is not as many places as planned. Why then tianeptine much harder to find?
Contrary to rumors on the Internet, there is a conspiracy that has kept the drug in need, wherever they reside. The real reason tianeptine not sold in some regions because companies that manufacture, who decided not to enter certain markets, mostly likely because entry costs are prohibitive. That said, there are many in the psychiatric community who believe that the psychotropic drug tested over time could help millions were more widely available.
Who should take it?
Because it does not cause sedation or sleep problems, tianeptine is appropriate for patients who are susceptible to the adverse effects of most antidepressants, including the elderly and those who are recovering from alcohol withdraw. The drug can also be of great benefit to those suffering from anxiety disorders. How?
At last count, forty million American adults with some form of anxiety on a regular basis. About a third of those who seek treatment also report regular sessions of depression, since both disorders are highly correlated. In other words, those are often depressed and anxious vice versa. And since both tianeptine is an antidepressant and anxiolytic activity, can be used to treat both diseases simultaneously.
Why does it work?
While recent discoveries have provided a necessary idea, researchers have only scratched the surface when it comes to the complex series of chemical reactions tianeptine intake triggers in the brain. At its most basic level, we know that unmanaged stress causes the adrenal glands secrete excess cortisol, a hormone powerful stress. The main function of this steroid is to increase blood sugar and give the body energy and strength you need to repel the danger. Also known as the fight-or-flight response to stress or this involuntary process tends to decrease mood levels to help them focus on the task at hand. But when cortisol and other stress hormones remain at high levels for extended periods of time, can cause clinical depression. In fact, cortisol levels are now used as a biomarker for the risk of suicide.
Current evidence suggests that tianeptine works to prevent and even reverse the neuronal damage that is caused by stress or stress hormones like cortisol. Researchers also believe that the continued use of the drug may help normalize the hypothalamic-pituitary-adrenal system (HPA), which is responsible for monitoring and release of cortisol and other stress hormones. In other words, tianeptine can help those at risk are referred to environments and situations a little better for the normalization of HPA stress system.
As with many psychotropic drugs, tianeptine does not work for everyone: Research shows that perhaps as much as a third of users do not respond as expected. That said, tianeptine has been shown effective in cocktails when antidepressants alone or the use of a single first-line drug, failed. The most promising of all is clearly the ability of the drug to protect against and even reverse the effects of hypercortisolism – a condition resulting from prolonged exposure to excessive levels of cortisol exposure; and one that is strongly associated with major depressive episodes. The long-term use of tianeptine can protect against relapse and recurrence of clinical depression.
At the end of the day, depression is a complex disorder that can never understand. What we do know, though, is that the new tools we have to fight against the melancholy, the best hope that we can offer those who suffer its devastating effects. Tianeptine may not be the main church stands suggest, but what you have to offer is valuable and unique. A drug-cum-anti-anxiety mood lightening established that it is well tolerated and relatively safe, abandonment of tianeptine by the Anglo-American psychiatric community is shortsighted and undeserved.
Tianeptine, the Forgotten Antidepressant?
Forgotten Antidepressant, tianeptine, Antidepressant
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